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Monitoring of serum digoxin concentration SDC is one of the approaches for controlling the safety of the long-term digoxin treatment, however, the benefits from SDC monitoring in paroxysmal arrhythmias have not been studied. To evaluate the potential benefits of digoxin laboratory monitoring at the initiation of digoxin therapy in patients with paroxysmal atrial fibrillation AF. Material and methods.

SDC was measured in 20 hours after digoxin treatment initiation and after restoration of sinus rhythm, or in 1 week after the start of therapy if arrhythmia persisted.

The intake of digoxin was not an independent factor for the occurrence of cardiac rhythm disturbances. Comparison of the direct SDC measurements and the calculated values obtained with the valid calculators developed for the long-term digoxin use did not show reliable reproducibility of the calculated data. The existing empiric SDC calculators are not suitable as an alternative to the direct measurement.

Further studies are needed to determine the clinically valid borderline values of the safe SDC in the condition of rapid digitalization. Artem A. Uchebniy per. Petersburg,Universitetskaya nab.

Petersburg, Aleksandr E. Universitetskaya nab. Andrey G.

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Petersburg,Malaya Konyushennaya ul. Ouyang A. Meta-analysis of digoxin use and risk of mortality in patients with atrial fibrillation. Am J Cardiol. Hussain Z. Digoxin use and digoxin toxicity in the post-DIG trial era. J Card Fail. Ziff O. Digoxin: the good and the bad.

Trends in Cardiovascular Medicine. Kirchhof P. Eur Heart J.

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